Ceruloplasmin
CPT Code: 82390
Order Code: C1369
ABN Requirement: No
Synonyms: Wilson’s Disease; Copper Oxide
Specimen: Serum
Volume: 1.0 mL
Minimum Volume: 0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)
Collection:
Serum:
- Collect and label sample according to standard protocols.
- Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
- Let tube stand in a vertical position to allow blood to clot 30 minutes.
- Centrifuge for 10 minutes.
Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.
Stability:
Ambient (15-25°C): 7 days
Refrigerated (2-8°C): 60 days
Frozen (-20°C): 90 days
Deep Frozen (-70°C): 90 days
Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits
Methodology: Immunoturbidimetric
Turn Around Time: 4 days
Reference Range:
| Age | Male, mg/dL | Female, mg/dL |
| 0-30 days | 8-25 | 3-28 |
| 31 days-11 months | 15-48 | 15-43 |
| 1-3 years | 25-56 | 29-54 |
| 4-6 years | 29-56 | 26-54 |
| 7-9 years | 25-52 | 23-48 |
| 10-12 years | 21-51 | 21-48 |
| 13-15 years | 20-50 | 21-46 |
| 16-18 years | 20-45 | 22-50 |
| >18 years | 18-36 | 18-53 |
Intended Use: Evaluation of Wilson’s disease (hepatolenticular degeneration), liver cirrhosis, and copper deficiency.
Limitations: Oral contraceptives may cause increased values. Because ceruloplasmin is an acute phase reactant, use caution in interpreting results where inflammation or infection are present.
Clinical Significance: Ordered with a blood or urine copper test, ceruloplasmin helps in the diagnosis of Wilson’s disease.
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.